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Secrin (Glibenclamide)

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Secrin belongs to a class of drugs known as sulfonylureas. These drugs act by closing ATP-sensitive potassium channels on pancreatic beta cells. The ATP-sensitive potassium channels on beta cells are known as sulfonylurea receptor 1 (SUR1).

Other names for this medication:
Afdiex, Benclamet, Betanase, Betrol, Daocon, Daonil, Diabetnil, Diabetrol, Diolin, Duotrol, Eumet, Giclamide, Glibet, Glifil, Glime, Glucomin, Glucored, Glucosil, Glunil, Glutowin, Glybid, Glybovin, Glycurb, Glycurub, Melitus, Monomet, Pionorm, Sycored, Symet, Triglycomet

Similar Products:
Zantac, Indocin, Lipitor, Bactrim, Aristocort, Albenza, Floxin, Famvir, Coreg, Microcid, Septriol, Pedimite, Prosip, Omefer, Acvirall, Citolex, Niftene,

Also known as: Glibenclamide


Secrin and metformin is a combination of two oral diabetes medicines that help control blood sugar levels.

Secrin and metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Secrin and metformin is not for treating type 1 diabetes.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For type 2 diabetes:
    • For oral dosage form (tablets):
      • Adults—At first, 2.5 to 5 milligrams (mg) once a day taken with breakfast or the first main meal. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
      • Children—Use and dose must be determined by your doctor.


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Secrin dosage information

Side effects

The most common side effects associated with Secrin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For Secrin, micronized, the following should be considered:

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pylori has been demonstrated previously, but little is known about the mechanism. strain SC2, an aerobic methanotroph with high-affinity methane oxidation potential. Further investigation of the mechanism by which Vpr activates the ATR pathway reveals an increase in chromatin binding of replication protein xanax overdose treatment ems A (RPA) upon Vpr expression. beta-Sonogel-carbon electrodes: a new alternative for the electrochemical determination of catecholamines. Interestingly, in the microbial world, several organisms possess the genes encoding two, or even three different RNRs that present different structures and allosteric regulation. Constitutively active (ca)ALK1, but not caALK5, phosphorylated endoglin on cytosolic domain threonine residues. The proposed risk-adjustment model can be applied for the fair comparisons of the rates between hospitals. Little data exist on the oral management of food boluses in neurologically normal children or children with cerebral palsy (CP).

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Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anemia. In two out of three patients, staff decided to intervene because of abnormal vital signs measured by study personnel, indicating a need to reevaluate monitoring routines at general wards. Such changes of viscosity will influence the delay time of the capillary, because they affect its flow resistance. We investigated the role of G protein kinase (GRK) 4gamma in essential hypertension in GRK4gamma mutant A142V transgenic mice. Abstract The presence and distribution of angiotensinogen and angiotensin II (All) were demonstrated in rat pituitary by immunocytochemical staining with the avidin-biotin-peroxidase method, using primary polyclonal antibodies specific for angiotensinogen and All. The presence of ICSA was assessed by incubating serum immunoglobulin fractions with normal Wistar rat islet cells and identifying cell-bound immunoglobulins by indirect immunofluorescence and by a complement-induced cell toxicity reaction. Two animals died after the implantation not related to the iron stent.

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The total concentration of the jet fuel and its main hydrocarbon families (n-paraffins, major aromatics) over the two cells is governed by the slow preferential flow of NAPL through the porous matrix, the rapid NAPL convective flow through vertical desiccation and sub-horizontal glaciotectonic fractures, and n-paraffin biodegradation in upper layers where the rates of oxygen transfer is not limited by complexities of the pore structure. Factors influencing enlargement rate of small abdominal aortic aneurysms. Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. Fistula-in-ano: an unusual presentation of chronic schistosomiasis. The parasympathetic nerve-sparing method using the Laparoscopic Neuro-Navigation technique in laparoscopic radical pelvic gynecologic surgery is a feasible and reproducible technique that preserves postoperative bladder function. Finally, the methods of program assessment and tracking are discussed. Solution structure of the factor H-binding protein, a survival factor and protective antigen of Neisseria meningitidis. The studies were evaluated according to their intervention type and use of computerized methods. In some cases the method helps escape removal of the salivary gland if the stone is localized inside the gland. Two epitopes suggest that VDAC (scVDAC) has its C-terminus exposed to the cytoplasm whilst two others are more equivocal and, when combined with published data, suggest a dynamic behavior.

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The recent identification of new poly(ADP-ribosyl)ating enzymes with distinct (non-standard) structures in eukaryotes and archaea has revealed a novel level of complexity in the regulation of poly(ADP-ribose) metabolism. The contribution of terminal galactofuranose residues to the antigenic specificity and to cross-reactivity of galactomannans isolated from five species of dermatophytes, Microsporum quinckeanum, Trichophyton granulosum, T. The acute inflammatory conditions include bacterial and viral infections, and the chronic conditions include sialoliths, strictures, chronic sialadenitis, sialectasis, and lymphoepithelial disease. Interestingly, despite the increase in AW responses during activation, simultaneous deflection of the PW and AWs produced VPM responses that resembled the PW response, as if the AWs were not stimulated. DMT1 provides positive cellular enhancement in a manner that is highly sensitive and dynamic, allowing greater spatial and temporal resolution for MRI compared to previously proposed MRI reporters such as ferritin. Relationship between transplantation viability and liver function in the isolated perfused liver. Treatment with immunoglobulin and/or plasma was effective in most of them.

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Effect of relative stimulus validity: learning or performance deficit?. Characterization of the DNA binding features of Saccharomyces castellii Cdc13p. From our point of view, certain technical aspects explain the excellent results obtained. This led to persistent hiccups as a result of repetitive stimulation of the reflex arc mediating hiccups. This study aimed to evaluate lung function in a surgically created chronic cyanotic neonatal lamb model after CPB and deep hypothermic circulatory arrest (DHCA) and to assess the role of nitric oxide (NO) in the pathogenesis of increased pulmonary vascular resistance. They deteriorate life quality and require a special system of rehabilitation measures.

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Preparation of composite fly ash (CFA) in the Ca(OH)(2)-H(2)O-CO(2) system is described. Correlation between spin-orbital coupling and the superparamagnetic properties in magnetite and cobalt ferrite spinel nanocrystals. Low density lipoprotein cholesterol (LDL-c) levels decreased and high density lipoprotein cholesterol levels (HDL-c) increased significantly. These results demonstrate that the suppression of NF-kappaB activation by zaluzanin-C and estafiatone might be attributed to inhibition of nuclear translocation of NF-kappaB resulting from blockade of the degradation of IkappaB, leading to suppression of the expression of iNOS and COX-2, which play important roles in inflammatory signaling pathways. Three boys demonstrated some evidence of decrement in responding with time-out.

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