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Amiloretic (Amiloride)
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Amiloretic

Amiloretic is a new, orally administered, potassium-sparing diuretic with mild natriuretic and diuretic properties. Its primary site of action is the distal tubule of the nephron where it selectively blocks sodium transport, thereby inhibiting sodium-potassium exchange.

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Also known as: Amiloride

Description

Amiloretic is a diuretic (water pill) and a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss. Brand name of Amiloretic is Amiloretic.

Dosage

Take Amiloretic by mouth with food. Amiloretic may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm. If you want to achieve most effective results do not stop taking Amiloretic suddenly.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Do not freeze. Keep container closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amiloretic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Amiloretic if you are allergic to Amiloretic components or to any ingredient in Amiloretic or any other sulfonamide (eg, sulfamethoxazole). Be careful with Amiloretic if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Amiloretic if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Amiloretic if you have allergies to medicines, foods, or other substances. Be careful with Amiloretic if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems, or systemic lupus erythematosus. Be careful with Amiloretic if you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated. Be careful with Amiloretic if you take potassium-sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease Amiloretic 's effectiveness; nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Amiloretic 's effectiveness and risk of kidney problems may be increased; barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, narcotic pain medicines (eg, codeine), or medicines for high blood pressure because the risk of their side effects may be increased by Amiloretic; diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because their actions and the risk of their side effects may be increased by Amiloretic; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Amiloretic; diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Amiloretic. Do not stop taking Amiloretic suddenly.

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