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Alpradol (Alprazolam)
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Alpradol

Alpradol is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Alpradol, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Alpradol is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Acalm, Alfresh, Alpracon, Alprastan, Alprawin, Alprine, Alprocalm, Alzam, Alzoset, Alzot, Ambulax, Ambutech, Anxit, Axizox, Calmef, Copax, Depoxit, Depwell, Endep, Flumusa, Flunix, Fluxozam, Meloprax, Morecalm, Notens, Nucalm, Poize, Pyrex, Rescalm, Resta, Rezolam, Selam, Sinzolam, Somnarest, Sowel, Sozox, Tancalm, Tenscure, Tensfree, Tensyn, Texidep, Trazopin, Tryzo, Xerodep, Zamitol, Zoldac

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Also known as: Alprazolam

Description

Alprazolam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alprazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Alpradol XR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.

Overdose

If you have been prescribed Alpradol for medical reasons, the best way to avoid a Alpradol overdose is to adhere to prescribed orders—closely monitor your dose and the time at which you take your medication. Track your Alpradol consumption in a notebook or on your phone. If you notice that you are taking a higher dose of the drug, taking the drug more often, or you want to consume more of the drug, talk with your doctor immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

It is very important to protect the orally disintegrating tablets from moisture. Remove and throw away any cotton packaging from the medicine bottle when you first use the medicine.

Detailed Alpradol XR dosage information

Side effects

The most common side effects associated with Alpradol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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Selective dorsal rhizotomy (SDR) is an effective treatment for reducing spasticity and improving gait in children with spastic cerebral palsy. For males field dependence did not correlate with any of the other variables. Cadherin-11/Cdh11 is expressed through early development and strongly during inner ear development (otic placode and vesicle). Investigating the effects of stimulus duration and context on pitch perception by cochlear implant users. Influence of bile acids on bile canalicular membrane morphology and the lobular gradient in canalicular size.

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Increased expression of microRNA-301a in nonsmall-cell lung cancer and its clinical significance. This study aimed to compare the effects of low and same dose of dexmedetomidine when added to lidocaine for intravenous regional anesthesia (IVRA) and when administered for premedication before IVRA. Among HIV-infected individuals, memory deficits with medium to large effect sizes were observed. The fatty tissue thickness of free flaps in each magnetic resonance imaging or computed tomography slice was measured. As a result, it was considered that, there were several other virulence factors belonging to the microorganism which played a role in the development mechanisms of the infection caused by C. Lateral and sigmoid sinus malformations are uncommon and dangerous anatomical variations that surgeons may encounter when performing a retroauricular approach.

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Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes. Lanthanum reveales globular structure of the middle layer of the gap junction. As investigative work progressed, the spectrum of diseases associated with a deficiency of A1AT increased. Hence, this study reveals an Achilles heel of Mtb that might be a promising target for tuberculosis chemotherapy. No significant chromosomal damage was observed in either the bone marrow or the spermatogonial cells in the animals during early nickel intoxication. Large international clinical practice guideline repositories, diabetes organisation websites, and electronic databases (Pubmed, Scopus), were searched to identify Clinical Practice Guidelines for adults with type 2 diabetes published 2005 to August 2014. We identified factors to help explain unexpected use in some cases. Serological diagnosis of rickettsial diseases of typhus and tick spotted fever group by the hemagglutination method.

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Two case-reports of the limb salvage treatment of osteosarcoma consolidated with obvious pathological fractures. MicroRNAs (miRNAs) consist of a growing class of short non-coding RNAs (ncRNAs) that negatively regulate the expression of genes involved in development, differentiation, proliferation, apoptosis and other important cellular processes. This strategy improves the spectral resolution by 1.5 fold, displays site-specific labelling patterns, and has advantages for collecting long-range distance restraints for structure determination of large eukaryotic membrane proteins by solid-state NMR. Although Gaucher disease has been divided into three clinical types, patients with atypical presentations continue to be recognized. Cyclic voltammetry method was adopted to evaluate the electrocatalytic activities of the synthesized electrodes toward oxygen reduction in KCl solution. Furthermore, potentially useful bioactive peptides can be limited by low bioavailability. Propagation calculations used a full-wave k-space method that accounts for spatial variations in density, sound speed, and frequency-dependent absorption and includes perfectly matched layer absorbing boundary conditions.

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This study includes 20 patients selected by clinical analysis and imaging criteria operated using laparoscopic radical cystectomy with prostate capsule sparing at our department in the period between 2008 and 2012. Economic burden of epilepsy in a developing country: a retrospective cost analysis in China. Ena/VASP proteins are implicated in a variety of fundamental cellular processes including axon guidance and cell migration. PGE1 produced a biphasic dose-response curve with constriction at low concentrations greater than 10(-7) M.PGI2 dilated coronary arteries at concentrations greater than 10(-8) M. There was no stress concentration on the inner or outer angles of the angled implants, on the notches along the implant body, or on any apex.

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Compared to HC, MSA patients showed significant activation over similar brain areas except for the cerebellum. The encapsulation of the oligonucleotide in form of solid complexes, the N/P ratio, as well as the PLGA type affected microspheres characteristics in term of loading, morphology, oligonucleotide distribution inside matrix and in vitro release profile. AAO participates in fungal degradation of lignin, a process of high ecological and biotechnological relevance, by providing the hydrogen peroxide required by ligninolytic peroxidases. In the spirit of the quantal theory, it was predicted that the point vowel, /i/, /a/ and /u/ would show lower standard deviations than the nonpoint vowels because these vowels are assumed to be produced at places in the vocal tract where small perturbations in articulation produce only minimal changes in the resulting formant frequencies. Effectiveness of the Yuzpe regimen of emergency contraception by cycle day of intercourse: implications for mechanism of action. Using 30-channel mass cytometry data, we show that Wishbone accurately recovers the known stages of T-cell development in the mouse thymus, including the bifurcation point.

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Enterovirus was isolated from these stool samples and then poliovirus and adenovirus were serotyped by neutralization test using specific anti-sera. The antibiotic effect of gentamycin in experimental acute Escherichia coli pyelonephritis. Significantly increased Th17 cell frequencies are observed in patients with coronary artery disease compared to healthy controls. Effect of double bonds on the dynamic properties of the hydrocarbon region of lecithin bilayers. In addition, a proposal is made for a strategy aimed at finding the optimal combination of procedures for each case. The impact of renal dysfunction on the outcome of patients with myocardial infarction: Does gender really matter?. We hypothesized that a lack of subjective perception of the disease state, possibly mediated by psychiatric or cognitive alterations, might contribute to the delayed initiation of a diagnostic workup. The B(22) parameter also reflects, in general, the influence of the salts of the Hofmeister series with regard to their salting-in/salting-out effect. Our results showed that levitation of ES cells at the highest employed acoustic pressure for 60 min does not modify gene expression and cells maintain their pluripotency. Insulin-like growth factor system and sporadic malignant melanoma.

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In normotensive as well as hypertensive subjects, physical activity lowers blood pressure. The structural changes caused by H1 histone depletion of calf thymus chromatin or nucleosome monomer were studied by using the criterion of accessibility to micrococcal nuclease. This study aimed to identify such predictors in QCT and voluntary treatment. A backward multiple linear regression model was developed with maximal reach as the criterion variable and kinematic variables as predictors. In all studies (a-minus 14C) uric acid and (methoxy-3H) inulin wereadministered. This review will focus on the tumor immune microenvironment, the expression of PD-1/PD-L1 and the effect of immune modulation using PD-1 or PD-L1 inhibitors in patients with head and neck, prostate, urothelial, renal, breast, gastrointestinal and lung cancers. The results obtained are compared with those from a similarly large number of men examined in identical circumstances. The amount of A substance in the fractions was related to the A subtype (A1 or A2) and to the Lewis and secretor phenotype of the donor. Influence of hemodialysis on the homogenicity of repolarization phase of action potential of myocardium. The slides are more permanent than diazo slides, and the process is faster and less expensive.

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Modification of surgical technic in partial resection of the larynx. Owing to study heterogeneity, pooling of diagnostic outcomes in meta-analysis was not conducted. A case report is presented of a 13-year-old girl with severe pneumonia who was treated with prolonged cardiopulmonary bypass during which time she developed a clinical picture simulating brain death with marked depression of cerebral cortical activity on two successive EEGs. Sources of diagnostic error can be attributed to the fact that not all patients with extradural haematomas have marked external evidence of trauma and a significant number, particularly children and adolescents, show no radiological, clinical or for that matter, post-mortem evidence of a fracture. Intraoperative regional cerebral blood flow during carotid endarterectomy.

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The experimental increase in FFA by a neutral fat infusion in 8 normal subjects decreased this oxidation in spite of the insulin rise. Critically ill patients supported with extracorporeal membrane oxygenation are transported within the hospital to the radiology suite, cardiac catheterization suite, operating room, and from one intensive care unit to another. CP12 plays an important role in the regulation of the Calvin-Benson-Bassham Cycle participating in the assembly of a supramolecular complex between phosphoribulokinase and glyceraldehyde 3-phosphate dehydrogenase, indicating that calcium signaling could play a role in regulating carbon fixation. Many influences can cause memories to change or even be created anew, including our imaginations and the leading questions or different recollections of others. Radiotherapy of the lomboaortic lymph nodes in carcinoma of the cervix uteri. Comparison of airway scope and videolaryngoscope portable VLP-100 in the presence of a neck collar--a manikin study. pylori vacuolating toxin (VacA) to induce gastric epithelial cell apoptosis. The new perimeter and proprietary software enable to carry out tests automatically (without the need to press any button).

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We performed phylogenomic analysis of the catalytic core of NADH:quinone oxidoreductases of type 1 (NDH-1). Arthrographic and gross pathologic material is presented sumycin suspension in support of this hypothesis. Battery deterioration was heralded by an increase in cardiac rate. Married students in the light of socio-political measures in East Germany--student marriage, student family 1964-1977. Semicarbazide (SC), an antivitamin B(6), was injected directly into the superior colliculus of the mouse. Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.

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Chloroquine does not affect fatty acid synthesis by isolated hepatocytes. Versatility of the distally based superficial sural flap for reconstruction of lower leg and foot in children. The Evidence Based Medicine (EBM) paradigm requires that results from Randomized Controlled Trials (RCTs) must be assessed for validity before is it ok to miss a dose of abilify being assimilated. Collateral vessels on CT angiography predict outcome in acute ischemic stroke. Although slow MAS is a powerful method, its applications are hindered by experimental challenges. Males weighed more than females at 12 weeks, but sex did not affect serum cholesterol concentration, triglyceride concentration, or cholesterol absorption. Solving how insulin regulates glucose transport into skeletal muscle and adipose tissue remains a fundamental challenge in biology and a significant issue in medicine. A 43-year-old woman had a 1-month history of monotonic speech and difficulty singing. Selective knockdown of Lsd1 in the dorsal wing disc caused an atrophied wing phenotype.

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A homogenization method for thin microstructured surfaces and films is presented. The spurious level was significantly below that obtained in a self-sustained OEO after inserting a narrowband electronic filter with a Q-factor of 720 into the cavity. To establish a method for isolation and culture of subcutaneous microvascular endothelial cells (MVEC) from small human tissue biopsies to compare gene and protein expression of insulin signaling molecules in MVEC from insulin-resistant and healthy control subjects. We demonstrated that DHM can markedly induce apoptotic cell death and autophagy in HNSCC cells. Effect of Autoantibodies to Erythropoietin Receptor in Systemic Lupus Erythematosus with Biopsy-proven Lupus Nephritis. However, the detailed mechanisms of the chemoresistance of ATLL have never been elucidated. In chronic inflammatory diseases such balance is compromised, resulting in norvasc 10 mg dosage persistent inflammation and impaired healing.

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Applicability and validity of the Dutch version of the Montreal Cognitive Assessment (moCA-d) in diagnosing MCI. One case developed rectal stenosis that was treated by dilatation before colostomy closure. Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. First-line gefitinib, compared to chemotherapy, is associated with longer progression-free survival, higher response rate, better toxicity profile and quality of life, and its administration as first-line warrants that all patients have the chance of receiving an EGFR inhibitor. Characterization and evaluation of 2.5 MV electronic portal imaging for accurate localization of intra- and extracranial stereotactic radiosurgery. In an attempt to identify improved drugs for treating the disease, we have carried out high throughput screening of a number of small molecule libraries with the aim of identifying lead compounds with balanced activity against all life stages of Schistosoma. The psychological and physiological effect of hydration on male college athletes. This review mainly deals with the research progress on endophytic fungi for producing plant-derived bioactive compounds such as paclitaxel, podophyllotoxin, camptothecine, vinblastine, hypericin, and diosgenin. Although, zones of inhibition were found in all the groups, 5mcg Sparfloxacin and 30mcg Augmentin showed maximum antimicrobial activity against E.faecalis. The increase of circumferences of the eyeball paralleled each other throughout the 12th to the 40th week.

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The second (trauma center level) surveyed practice patterns of National Trauma Data Bank hospitals. Serum alpha 1 acid glycoprotein measurement demonstrated no evidence of inflammatory response to gluten challenge. These viral disulfide catalysts belong to a family of sulfhydryl oxidases that are dimers of a small five-helix fold containing a Cys-X-X-Cys motif juxtaposed to a flavin adenine dinucleotide cofactor. The excellent properties of this material find their use in the treatment of various disorders of the skeletal system. Erythrina speciosa is a Neotropical tree that grows mainly in moist habitats. The present study was carried out to clarify whether the L-dopa effect could be mediated through an improvement of the brain neutral amino acid patterns, since it competes for the same transport carrier at the blood-brain barrier. Using a scaling analysis comparing two governing mass transport timescales, we demonstrate that there exists a transition from diffusion-limited to kinetic-limited dynamics at the silicone oil-water interface. The SOF community can be the change agent for the DVPRS and CIM approaches to pain management, which will in the end serve to accelerate recovery and return SOF operators to duty faster and with an enhanced ability to perform with less pain. Either the protein needs to be targeted to the endoplasmic reticulum in eukaryotes or to the prokaryotic periplasm.

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At day 3, concentrations of several trace elements, including Cu, Zn, Fe, Ca, V, and Mn, showed pronounced changes in both the serum and the pancreas. Despite advances in imaging techniques, cervical injuries may still be missed. The present study was conducted to determine the distribution of Caspase 8 IVS12-19G/A, Caspase 8D302H, Caspase 8 -652del and Caspase 8 -678del polymorphisms (as frequency distribution of caspases in Indians generally is not yet known), which was then compared with different populations globally. Several questions concerning aetiology and treatment of neurological events are raised. In all cases, an individualized, adequate diet (enteral formula or parenteral solution) is obligatory to decrease the occurrence of overfeeding and its undesirable consequences. Escherichia coli B N5-methyltetrahydrofolate-homocysteine methyltransferase: sequential formation of bound methylcobalamin with S-adenosyl-L-methionine and N5 lanoxin medication class -methyltetrahydrofolate. Congenital cataract associated with persistent fetal vasculature: findings from IoLunder2.

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