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Alpostin (Alprostadil)

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Alpostin is a medication used to treat erectile dysfunction. Alpostin (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of Alpostin on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora.

Other names for this medication:
Alpostin, Caverject, Edex, Muse, Prostin, Vitaros

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Also known as: Alprostadil


This medication is used to treat male sexual function problems (erectile dysfunction). It works by helping the blood flow into the penis to achieve and maintain an erection. This medication is not for use in women or children. This medication is not recommended for use in men with penile implants.


A healthcare provider will give your first dose and teach you how to properly use the medication by yourself.

Follow all directions on your prescription label and read all medication guides. Use the medicine exactly as directed.

Alpostin is used only when needed. An erection should occur within 5 to 20 minutes and last up to 60 minutes.

Alpostin injection is injected into the side of the penis.

Alprostatil transurethral pellet is a very small suppository to be inserted into the opening of the penis (the urethra).

Do not use more than 2 pellets in one day. Do not use more than 3 injections per week. Wait at least 24 hours between each injection.

Ask your doctor or pharmacist if you don't understand how to use the injection.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it.

Do not reuse a needle or syringe. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

Call your doctor if a needle breaks while you are injecting Alpostin. If you can grasp the broken end, remove the needle right away.

Your doctor should check you every 3 months to be sure Alpostin is not causing harmful effects on your penis.

Storing Alpostin:

Keep pellets in their original foil pouch in the refrigerator. You may store a pouch at cool room temperature for up to 14 days. Protect from freezing or extreme heat. Do not store in a closed automobile or in luggage while traveling. Store Alpostin injection vials at cool room temperature. The 40-microgram strength should be used within 3 months or before the expiration date on the label. After mixing a Caverject injection, keep it at room temperature and use within 24 hours.

Detailed Alpostin dosage information


If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, painful/prolonged erection.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Alpostin for Injection while in the powder form can be stored at room temperature (between 15 and 25 °C or 59 and 77 °F) for 3 months. After it is mixed, the solution must be used immediately or within 24 hours and not refrigerated or frozen. Suppositories may be stored at room temperature.

Side effects

The most common side effects associated with Alpostin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Before using Alpostin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: penis conditions (e. g. , angulation, fibrosis/scarring, Peyronie's disease), blood system cancers (e. g. , leukemia, multiple myeloma), sickle cell anemia. Use of this drug does not protect against sexually transmitted diseases (e. g. , HIV, hepatitis B, gonorrhea, syphilis). To decrease your risk of infection, always use an effective barrier method such as a latex or polyurethane condom during all sexual activity. Consult your doctor or pharmacist for more details.

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