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Alendronate is used to prevent and treat certain types of bone loss (osteoporosis) in adults. Osteoporosis causes bones to become thinner and break more easily. This medication works by slowing bone loss. Alendronate belongs to a class of drugs called bisphosphonates.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

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Alendronate (alendronate) is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Alendronate is used in women to treat or prevent osteoporosis caused by menopause and in men and women to treat osteoporosis caused by taking steroids.

Alendronate is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.


Take Alendronate exactly as prescribed by your doctor. Alendronate is taken either once daily or once per week. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Alendronate first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take this medicine only once per week, take it on the same day each week and always first thing in the morning.

Take with a full glass (6 to 8 ounces) of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water.

Do not crush, chew, or suck on an Alendronate tablet. Swallow the tablet whole.

For at least 30 minutes after taking Alendronate:

Do not lie down or recline. Do not take any other medicine including vitamins, calcium, or antacids.

Pay special attention to your dental hygiene while taking Alendronate. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate.

Alendronate is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

Your doctor will determine how long to treat you with this medicine. Alendronate is often given for only 3 to 5 years.

Detailed Alendronate dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Drink a full glass of milk and call your local poison control center or emergency room right away. Do not make yourself vomit and do not lie down.

Overdose symptoms may include muscle cramps, numbness or tingling, tight muscles in your face, seizure (convulsions), irritability, and unusual thoughts or behavior.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alendronate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Alendronate if you are allergic to alendronate, or if you have:

low levels of calcium in your blood (hypocalcemia); or problems with the muscles in your esophagus (the tube that connects your mouth and stomach).

Do not take Alendronate if you cannot sit upright or stand for at least 30 minutes. Alendronate can cause serious problems in the stomach or esophagus. You must stay upright for at least 30 minutes after taking this medicine.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

trouble swallowing; problems with your stomach or digestion; low levels of calcium in your blood; a dental problem (you may need a dental exam before you begin taking Alendronate); kidney disease; or any condition that makes it hard for your body to absorb nutrients from food (malabsorption).

In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use Alendronate, the more likely you are to develop this condition.

Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem.

Alendronate has also been reported to cause fractures, or broken bones, in the large bones of the leg. Tell your doctor if you have any leg or groin pain while using Alendronate.

Talk with your doctor about the risks and benefits of using this medication.

It is not known whether Alendronate will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Stop using the medicine and tell your doctor right away if you become pregnant.

It is not known whether alendronate passes into breast milk or if it could harm a nursing baby. Ask your doctor about any risk.

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MR imaging analysis by reviewers who were unaware of clinical status included comparison of volume indexes (computed as the product of three axis measurements) of the spleen and each segment of the liver, and changes in hepatic contour, iron or fat deposition, and presence of varices and collaterals. Western blot and immunocytochemical analyses verified the presence of ProSAP1/Shank2 and ProSAP2/Shank3 proteins in thymic tissue. In vivo augmentation of the cyclic nucleotide pathway by PDE inhibition may induce HbF slightly, but strikingly improves hemodynamic and functional status in SCD. Functional performance was measured by timed motor performance and by questionnaires on functional performance. Cardiac output during exercise measured by acetylene rebreathing, thermodilution, and Fick techniques. Instead, rods increased their outer-segment diameters, accommodating the extra rhodopsins without changing the rhodopsin packing density. Long-term somatotropic and galactopoietic effects of a (1-30) ethyl amide analog of growth hormone-releasing factor. Using the analytical expressions of limited diffraction beams, arbitrary continuous wave (cw) or pulse wave (pw) fields of 2D arrays can be obtained with a simple superposition of these beams.

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Temporal tuning properties along the human ventral visual stream. The test formulation was noninferior to the innovator for the primary outcome of MiniRQLQ score. Adhesion experiments on fibronectin-coated surfaces that mCRP on human blood monocytes may act as a selectin-like adhesion molecule, mediating initial carbohydrate-specific contacts which are followed by peptide-specific recognition via integrin receptors. It examines likely developments in the knowledge base as well as addressing the clinical implications going forward. Uptake of meta-analytical overviews of effective care in English obstetric units. Of 4 pigs that had follow-up radiography, all had evidence of mild to moderate degenerative joint disease. Over 100 different stent designs are currently being marketed or are in evaluation for vascular and non-vascular indications. The colonies were cloned by limiting dilution and screened in a monolayer proliferation assay for sensitivity to TGF beta 1 and TGF beta 2 isoforms. Objective instrumental methods should minimise observer variation, but unless a simple non-invasive method can be developed, the uptake of such technology will probably be limited by cost and lack of practicality. Some of these low-efficacy, high-affinity ligands elicited antagonistic activity.

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injection of 0.1 mmol/kg Gd-DTPA using an inversion recovery sequence. Social workers in the substance abuse treatment field: a snapshot of service activities. Here, the authors report reanalyses of two offender data sets that included scores on the PPI along with various theoretically relevant criterion variables. Working with patients who have values that differ from the mainstream culture can make delivery of health care complex and challenging. A 60-year-old man presented with spontaneous enterocutaneous fistula in the left groin region without signs of peritonitis. Twenty-one patients with pruritic urticarial papules and plaques of pregnancy (PUPPP) were reviewed. Radionuclide studies on gastric evacuatory function in health and in the duodenal ulcer disease.

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Immunoblotting revealed 2 distinct groups of cross-reactive antigens, a 33-35 Kd group that was proteinase K sensitive but not reduced by periodate oxidation, and a 14.4-26.5 Kd group whose activity was reduced by periodate but not proteinase K, indicating the presence of both protein and carbohydrate genus antigens. The bond-strength of the acrylate with different percentages of MAPTAC was determined in a shear mode. In this study, we investigated whether genetic polymorphisms of the interferon gamma (IFNG) gene were associated with the susceptibility of ossification of the posterior longitudinal ligament (OPLL) in the Korean population. We have previously shown that 11q13.5 amplification was associated with significantly shorter overall survival in ovarian cancer patients, but the molecular mechanisms of how amplification of this locus contributes to disease aggressiveness remain unclear. Moreover, in this population-based study, neither IgG nor IgM OxLDL autoantibodies were independently predictive of atherosclerosis progression in the carotid arteries. Obesity and preterm birth: additive risks in the progression of kidney disease in children.

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The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells. compared with plasma, inactive renin in amniotic fluid eluted as a broader and sometimes diphasic peak, suggesting heterogenicity. Long-term and frequent use of NSAIDs may enhance the chemopreventive effect of aspirin against colorectal neoplasia. Cortisol was measured using a time-resolved fluorescent immunoassay. differential interference contrast and transmission electron microscopy) and marker enzymes for biochemical characterization. The enteropathogenic effect is probably due to Shiga-like toxin, a cytotoxin that is active on Vero cells and has also been called Verotoxin.

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Combined hematopoietic and lentiviral gene-transfer therapies in newborn Twitcher mice reveal contemporaneous neurodegeneration and demyelination in Krabbe disease. Focal overexpression of TGFalpha in either the median eminence or preoptic area of the hypothalamus accelerates puberty. The likelihood of receiving a TBI diagnosis or a significant injury to other body regions and differences in injury severity and in-hospital mortality between helmeted and unhelmeted ATV riders were compared. However, the methodologic and other limitations characterizing most of these studies preclude drawing firm conclusions. The combination of classical forward genetics with recently developed genome-wide, gene-indexed mutant collections is beginning to revolutionize the way in which gene functions are studied in plants. Study of the pulmonary function in chronic chagasic heart disease. Also platelet aggregation rate approached normal level after calcium therapy. Chronic pulmonary disease negatively influences the prognosis of patients with advanced prostate cancer.

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A quantitative sutdy of vertebral displacement and angulation in the normal cervical spine under axial load. On the interpretability of quantitative structure-activity relationships (QSAR). We validated our method using different simulated artificial data sets and one real data set, and we report encouraging results. A 76-year-old female presented with malabsorption and was subsequently shown to have jejunal villous atrophy. In humans, several types can be distinguished and a classification has been made based on their mode of inheritance, age of onset, severity, and associated clinical symptoms. Effects of reboxetine and desipramine on the kinetics of the pupillary light reflex. The 1st case was a 65-year-old female, and another case was a 60-year-old male. The conservative treatment of lodine drug info complete tears of the anterior cruciate ligament in skeletally immature patients. spp., Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae. Grandparents experienced greater difficulty, more frustration, and felt less informed to carry out their role than was reported by parents and grandchildren.

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The diagnostic performance of FibroScan depends on the care and quality of the procedures used to measure liver stiffness. The RT-PCR-identified Fas and FasL expression and apoptosis in mouse hepatoma starlix dose MH-22a and histiocytic sarcoma J-774 clonal lines coupled with in vitro cultivation with syngenic splenocytes. Kinetic studies of recA protein binding to a fluorescent single-stranded polynucleotide. Some of these effectors possess functional domains that are conserved in UPS enzymes, whilst others contain novel domains with ubiquitination activities. In the second section, the results of controlled clinical studies on the efficacy of antidepressants in suicidality are presented.

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Effect of resistance and aerobic training on regional body composition in previously recreationally trained middle-aged women. Agg2p localizes to the proximal flagellar membrane near the basal bodies. Magnetic variation induced by structural transformation from coordination chains to layers upon dehydration. Although populations with low MHC diversity tend to be more susceptible to pathogens, some bottlenecked populations persist and even increase in numbers despite low MHC diversity. Whole genome amplification for array comparative genomic hybridization using DNA extracted from formalin-fixed, paraffin-embedded histological sections. When cells were treated with UK-2A or with AA the tramadol 50 mg iv intracellular ATP content decreased significantly within 5 minutes in glucose-free medium to almost the same extent in both cases.

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In the visual cortex, pinwheel centers, which appear as point singularities in orientation maps, are likely to be found at the centers of ocular dominance columns in normal cats and monkeys. There was no statistical difference between the results of open sheath versus closed sheath in these two groups of patients treated postoperatively with the same controlled motion rehabilitation program. Distribution of the C-terminal glycopeptide of the vasopressin prohormone in rat brain: an immunocytochemical study. Further electrochemical tests involved cyclic voltammetry (CV), galvanostatic charge-discharge (GCD) and electrochemical impedance spectroscopy (EIS) in 1 mol L(-1) HClO(4) solution. Preliminary trials on infants demonstrate that the instrument functions satisfactorily in the newborn intensive-care unit. benign) and UICC disease stage in consecutive 5-year periods (1994 - 1998 and 1999 - 2003) were compared. The cannulated screw fixation technique can maintain the rigid fixation of fracture fragments and allow an early return to work and sport activities.

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The edges that are missed or blurred by the edge detector are reconstructed through the addition of the artificial dissipation terms. We measured local visual acuity thresholds at 27 discrete locations within 21 degrees diameter using the Functional Fundus Imaging System (FFIS), a psychophysical system that measures visual acuity as a function of visual field location, and local ERG responses within 45 degrees diameter using the mfERG. A trend difference in correlation magnitude was also found between men and women when comparing anxiety with pain frequency, with the magnitude of correlation being higher in men. Age at menarche is considered a reliable prognostic factor for idiopathic scoliosis and varies in different geographic latitudes. Monodisperse icosahedral Ag, Au, and Pd nanoparticles: size control strategy and superlattice formation. To elucidate the mechanisms of assembly for nebulette in the Z-line, the complete coding sequence or fusions of nebulette domains with green fluorescent protein (GFP) were expressed in cardiomyocytes and fibroblasts.

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Eight patients presented histopathologic findings consistent with the diagnosis of TA. The experimental and control group were fit with a hearing aid that has the capability of storing use time data for later analysis. This paper documents actual patient usage of a hospital-based alternative medicine clinic that has been operating on a conventional healthcare campus since 1993. Beta 2-microglobulin in liver cirrhosis: study of a local synthesis in ascitic fluid. Of the potential new indications studied, the strategy that may prevent most cases is lowering the recommended age for universal vaccination to 50 years. Immunological specificity of heat-stable opsonins in immune and nonimmune sera and their interaction with non-encapsulated and encapsulated strains of Staphylococcus aureus. A prominent role for SK was found in an unusual hyperkalemic patient with interstitial nephritis when PRA was suppressed and the elevated SK showed a definite postural rise inducing dramatic increases in PA in the upright posture. Outdoor recreation exhibited a positive association with delinquency. Circulating fibrocytes in ischemia-reperfusion injury and chronic renal allograft fibrosis.

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A case of eight simultaneous brain abscesses in the right cerebral hemisphere, treated medically after puncture of two of them, is reported. The set of all knowledge spaces on a given set of items or questions is investigated with respect to order theoretic and metrical properties. To investigate the function of the N-terminal region further, we constructed the N-terminal truncated recA gene lacking the portion corresponding to the N-terminal 33 residues and prepared a large amount of its gene product. Examining the intersection of sex and stress in modelling neuropsychiatric disorders. These results are consistent with the possibility that myd is the mouse homolog of FSHD. Therapeutic approaches aimed at quenching PAI-1 activity after thrombolysis might be of interest to improve the efficacy of thrombolytic therapy for acute myocardial infarction. We carried out a study to describe the epidemiology of postpartum hemorrhage in British Columbia, Canada, between 2000 and 2009. Examination of the effects of monensin on isolated mesoderm cells in culture using interference reflection microscopy indicated that the spreading of these cells was reduced independently of the changes in the extracellular matrix of the embryo. The therapeutic effect of transfer factor (TF) from healthy donors was investigated in two children with extensive intractable atopic dermatitis, recurrent pyogenic skin infections, hyperimmunoglobulinaemia E, defective neutrophil chemotaxis and depressed cell-mediated immunity. Recombinant FruA was shown to bind to an essential regulatory sequence located slightly downstream of the MrpC2 aceclofenac tablet ip -binding site in the fmgBC promoter region.

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To determine the association between obesity measures and albuminuria in adults with type 2 diabetes. Soft tissues sarcomas: good medical practices for an optimal management. Iron deficiency has been shown to result in impaired control of body temperature, resulting in an increase in catecholamine levels. These findings are discussed in term of local and remote factors influencing the epileptogenic focus. With thin-slab MIP images, the detection of the laminar borders was more straightforward. Modified single-incision distal biceps tendon repair using three suture anchors: surgical technique. Preventing ventilator-associated pneumonia: tiptoeing through a minefield. Identify correlates of health-related and future-oriented goals of adolescents with cancer. Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor. Eight boys and 12 girls between 7 and 12 years old (mean age 9) with recurrent urinary tract infection, an interrupted or fractional voiding pattern and high post-void residual urine in whom behavioral, short biofeedback and alpha-blocker therapies had failed were included in the study.

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Conduction block and functional denervation caused by Tullidora (Karwinskia humboldtiana). An appraisal of ultraviolet lamps used for the phototherapy of psoriasis. Pulsatile GnRH stimulates normal cyclic ovarian function in amenorrheic lactating postpartum women. Blood oxygen saturation during atrio-ventricular dissociation with wide-QRS complex tachycardias. Distal radioulnar joint instability in distal radius fractures: the role of sigmoid notch and triangular fibrocartilage complex revisited cardura medication classification . Specialist nurses make a valuable contribution to the care of the individual with inflammatory bowel disease yet there are still relatively few of these nurses in post. The VP4 protein expressed was recognized with a hyperimmunized serum directed against the rotavitus by immunoblot assay. Synaptic conductance values seen in normal saline were ineffective at changing the pyloric period throughout the pyloric cycle.

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The fluorescent protein-tagged structural protein for autophagosomes, the Atg8 protein, allows nondestructive detection of autophagy induction in plant cells and tissues by fluorescence microscopy. Expression profiling of glial genes during Drosophila embryogenesis. Treatment of trauma- and abuse-related dissociative symptom disorders in children and adolescents. Tuberculin skin test, chest radiography and contact screening in young children. Owing to the steady-state current, which is presumably ascribed to a noncylindrical geometry of the capillary tip, the relative magnitude of the hydrophobicity, or the affnity to the RTIL, of a series of ions can be determined from the half-wave potentials of voltammograms. We have shown that aqueous extract of IRFRC inhibits cell proliferation and stimulates apoptosis in HT-29 cells, and that this may be mediated by its ability to activate the caspase-3 pathway. A single toxicity assay cannot stand alone in determining the type and extent of damage or cell death mechanism. Axons from the two OSN types segregate already within the olfactory nerve and form distinct domains of glomeruli in the OB. Previous and recent data show that the injection-oral immunisation regime may be efficient. Uptake studies with disruption mutants confirmed this, and identified two additional genes for transporters of cysteine, TAT1 and TAT2, both very homologous to BAP2, BAP3, AGP1 and GNP1.

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