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Afeditab (Nifedipine)

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Afeditab is used to treat high blood pressure or angina (chest pain). For high blood pressure: Afeditab works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Afeditab works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
Adalate, Aprical, Atanaal, Calcibloc, Cisday, Conetrin, Coracten, Cordaflex, Cordalat, Fenamon, Menoprizin, Nifebene, Nifedipine, Nifedipino, Nifeslow, Nifical, Nipin, Nirena, Nycopin, Oxcord, Pabalat, Sepamit, Siopelmin, Tenif, Tensomax

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Afeditab XL. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Afeditab and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Afeditab are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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Cow milk is not responsible for most gastrointestinal immune-like syndromes--evidence from a population-based study. We apply this method to a study on the minimal residual disease (MRD) in childhood leukaemia. A test-system was developed on the basis of solid-phase enzyme-immunoassay using protein A/peroxidase conjugate for the determination of antibody levels to influenza virus in sera of humans who had experienced a natural infection or received a live influenza vaccine. Paroxysmal nocturnal hemoglobinuria (PNH) results from the expansion of a hematopoietic clone that is deficient in glycosylphosphatidylinositol-anchored molecules. Further research is needed to determine the optimal frequency of B-hCG testing. In the last 15 years several machine learning approaches have been developed for classification and regression. In the liver, partial heme deficiency led to less potent induction of CYP1A1 mRNA after beta-NF treatment.

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One must remember that biotechnology is still in its infancy, and that approaches will be greatly improved and more efficiently utilized in the future for the betterment of mankind. Moreover, cold stimulates the production of two species of N-oleoylphosphatidylethanolamine OEA precursors. Endoscopy, which was also extremely difficult, brought about the diagnosis of schwannoma in the region of the left ventricular band. MSM increased IGF-1R and GHR mRNA expression in osteoblastic cells. At lower levels of mutant accumulation, pathology is restricted to lower motor neurons, whereas higher levels cause more severe abnormalities and affect a variety of other neuronal populations. Women have a distinctly different pain experience than men after thoracic surgery and probably require novel and/or multimodal analgesic regimens to improve their comfort. For induction therapy in small vessel vasculitis cyclophosphamide or medium potent immunosuppressants such as methotrexate plus glucocorticoids should be used according to disease stage and activity. Allogeneic hematopoietic stem cell transplantation (SCT) may cure patients with hematologic malignancies, but it carries significant risks. This presents a novel mouse model in which future investigations into etiology of laryngeal clefts may be examined. The copper- and zinc-binding proteins were mainly separated into 3 different fractions.

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In the control group, ES cells differentiated freely without any inducing factors. Zeta potential (ZP) is a powerful tool to probe the electrostatic surface potential of biological materials and remains an untapped method for studying the interaction of nanoparticles with cells. In conclusion, the present study demonstrates that immune complexes provide the means for a non-interferogenic virus to induce IFN-alpha responses by NIPC. Obstructive sleep apnea (OSA) is a disorder characterized by repeated episodes of complete (apneas) or partial (hypopneas) cessations of breathing while sleeping. No organism isolated degraded AIB to isopropylamine as the primary reaction. Beginning with the wolf, man has created dog breeds that are hunters or herders, big or small, lean or squat, and independent or loyal. Relative importance of tonicity and of extracellular volume in salt depletion shock. Efforts should be focused on other types of interventions to improve rates of control of hypertension. The Eustachian tube was expedite in about 1/2 of cases with chronic suppurative otitis media, mild obstruction in about 1/4 quarter of cases, and serious obstruction and entire obstruction in about 1/10 of cases respectively.

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The folate receptor is important for the conservation of folate, mediating endocytosis of the vitamin. The viral progeny produced by infected keratinocytes was rescued and amplified by co-culture experiments performed with the HIV-1 high sensitive CEM-SS human T-cell line. Are we prepared for expectant mothers alone to choose the manner of delivery?. However, the species of ovarian HSPGs have not yet been identified. We have analyzed the specificity of mutations induced by ethyl methanesulfonate (EtMes) in mouse cells carrying a selectable bacterial gene. These two proteins are involved in pathogenicity and are the primary targets of the immune system.

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Malignant transformation of lymphadenosis benigna cutis: a possibly transformed case and B-cell lymphoma. Because of the potential risk of neonatal respiratory distress, prenatal diagnosis is valuable in the organization of a safe delivery. the sequential approach of treatment for advanced urothelial cancer using gemcitabine and carboplatine followed by paclitaxel seems to be a safer alternative to the combined triplet, but due to the limited number of patients this study failed to improve outcome. The occurrence of inter-esterified long-chain monomers in suberin brings a new insight in the understanding of the polyester structure of this biopolymer. Indications for various types of x-ray examination of patients with injuries of the eye and orbit. The microbiology of saturated salt solutions and other harsh environments, I. Conventional portal verification requires that a qualified radiation oncologist make decisions as to the set-up acceptability. RICK (receptor-interacting protein-like interacting caspase-like apoptosis regulatory protein kinase), a serine-threonine kinase, functions downstream of the pattern recognition receptors Nod1 and Nod2 to mediate NF-kappaB and mitogen-activated protein kinase (MAPK) activation in response to specific microbial stimuli. In hemodialysis patients an inverse correlation between WBC count as a marker of inflammation with serum Hcy level as a marker of nutritional status, further support the hypothesis of the malnutrition-inflammation cachexia syndrome. Bone tissue formation in extraction sockets from sites with advanced periodontal disease: a histomorphometric study in humans.

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Haemodialysis and peritoneal dialysis: metabolic alterations and nutritional status. Finally, what are the current and future strategies that may help stratify patients into high risk and low risk for the development of gastric cancer?. The IC muscles of the dolphin were located on the lateral aspect of the trunk and displayed an intercostal arrangement. The interpretation of diffraction patterns of two prototypical protic ionic liquids: a challenging task for classical molecular dynamics simulations. Glutathione S-transferases (GST) are involved in the detoxification of many potential carcinogens and appear to play an important role in the protection from carcinogens. The utility of capsule endoscopy and its role for diagnosing pathology in the gastrointestinal tract. Structural bioinformatic approaches have been used to study the cross-reactivity of inhalant allergens with labile food allergens (Bet v 1 family) as well as the cross-reactivity between stable food allergens such as members of the nonspecific lipid transfer protein family. Recent studies have suggested that elevated cellular lipid peroxidation may play a role in the development of cellular dysfunction and other complications of diabetes. Placental apoptosis is induced by TNFalpha in vitro and increased levels in utero characterize most failing pregnancies, intra-uterine growth restriction (IUGR) and labour. AFA shows promise in dealing with many types of signals, but like any fractal analysis method there are special challenges and considerations to take into account, such as determining the presence of linear scaling regions.

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Effect of stannous fluoride toothpaste on erosion-like lesions: an in vivo study. With respect to treatment of the problem, neither any form of physical therapy nor rehabilitation program could give long lasting benefit. A genetic and biochemical analysis of a polymorphism of bovine alpha S2-casein. This paper describes the Italian Cooperative Group on AIDS and Tumours (GICAT) experience on HIV-positive patients with SCCA. Shortly after invasion, the parasite modifies this vacuole by secreting a variety of proteins from electron-dense storage granules. Changes in lymphocyte single strand breakage and liver function of workers exposed to vinyl chloride monomer.

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To find the sources of lead currently poisoning people in Christchurch and Nelson and to review the presentation, epidemiology and symptoms of children with lead poisoning. Preload variables, global systolic function, and oxygen transport recorded simultaneously by three separate methods showed no need to increase the total fluid volume within 36 hours of a major burn. Self-esteem patterns distinctive of groups of drug abusing and other dysfunctional adolescents. Rho family guanine nucleotide exchange factors (GEFs) regulate diverse cellular processes including cytoskeletal reorganization, cell adhesion, and differentiation via activation of the Rho GTPases. Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder. The presence of these spirochetes underscores the ecological complexity within which Borrelia organisms are maintained and the need for diagnostic tests to differentiate among these organisms. A comparable population of cells in the ipsilateral lateral superior olivary nucleus was retrogradely labeled in cases with unilateral injections of tritiated glycine in the inferior colliculus. The mucociliary clearance of the bronchitics was significantly lower than clearance of a non-smoker control group. Interestingly, caveolin-1 expression was reduced while cyclin D1 and extracellular signal-regulated kinase (ERK) expression was increased. The CO(2) sequestration capacity of CFA under the flow-through conditions was approximately 0.019 g CO(2)/g CFA under the test conditions (solid dosage: 333 g/L, CO(2) flow rate: 40 mL/min, and solvent: seawater).

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The iodine-copper exchange reaction allows the direct preparation of various aryl, heteroaryl and alkenyl cuprates bearing a formyl group, thus allowing a direct synthesis of polyfunctional aldehydes without the need of protecting groups or an additional oxidation step. Oral health measurement in nursing research: state of the science. Endothelial progenitor cells homing to the orthotopic implanted liver tumor of nude mice. Encouraging results were obtained with this system in small scale clinical trials using unrefined agents. Before starting any kind of ART it is mandatory to perform diagnostic tests in all couples and to apply the correct therapy for any STD: treatment must always involve both partners and results must be carefully checked.

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In the present study, these cells were allowed to attach to tissue culture dishes for 1 h, rinsed and then incubated with latex beads for up to 72 h. Two mutants, K164N alpha and Y300F beta, have moderately decreased catalytic constants (kcat). Phytoestrogen alpha-zearalanol antagonizes homocysteine-induced imbalance of nitric oxide/endothelin-1 and apoptosis in human umbilical vein endothelial cells. Those lines showing low anxiety-like profiles in the EPM and OF (SHR and Floripa H) also showed low immobility in the FST. Six new diterpenes, (1R,2S,5S,7S,9R,10S,13R)-1,2,7-trihydroxypimara-8(14),15-diene (1), (1R,2S,5S,9S,10S,11R,13R)-1,2,11-trihydroxypimara-8(14),15-diene (2), (1S,5S,7R,9R,10S,11R,13R)-1,7,11-trihydroxypimara-8(14),15-diene (3), (1S,5S,9S,10S,11R,13R)-1,11-dihydroxypimara-8(14),15-diene (4), (5S, 6R,9S,10S,13R)-6-hydroxypimara-8(14),15-diene-1-one (5), and (1R,2S,5S,7S,9R,10S,13R)-1,2-dihydroxypimara-8(14),15-diene-7-one (6), along with four known diterpenes, have been isolated from the dichloromethane extract of whole plants of Kaempferia marginata. Apoptosis was evaluated by caspase-3/7 assay and caspase-9 cleavage detection. Sprouting and axonal re-growth are key components of functional generic equivalent of prilosec recovery, but are often counteracted by inhibitory molecules. All patients gave full informed consent and were assessed by an independent observer.

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Scalp penetration acupuncture is able to improve the prognosis of the patient with ACH by means of regulating the contents of plasma ET and CGRP. There is a worldwide trend towards a more liberal use of ventricular assist devices (VADs) as a definitive treatment for patients in end-stage heart failure. Confocal laser scanning microscopy: a new optical microscopic technique for applications in pathology and dermatology. The mutagenic potential of five chloroanilines and their succinamides and succinimide derivatives have been tested with two strains of Salmonella typhimurium (TA98 and TA100) with and without rat hepatic microsomal fraction. Concanavalin A-induced IL 2 production by splenocytes of DF-treated mice reached the maximal level between days 6 and 8, and it could be enhanced even on day 14. The occurrence of functional ovarian cysts during the use of phasic contraceptive pills is well established while not well appreciated by practicing physicians. Individuals with other gastrointestinal diseases, cancer and pregnant women were not xanax dosage 25 mg included. Bacterial death induced by expression of the intracellular portion of human Fas. Xenotransplantation workshop ponders science, safety of animal tissue grafts. IGF-II receptor immunoreactivity was found to be associated with neocortical pyramidal neurons within the core of the ischemic infarct itself.

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Metal exposure up-regulates expression of metallothioneins in coelomocytes, mainly amoebocytes. Our data indicate that selective stenting of the SFA after suboptimal balloon angioplasty results in intermediate patency rates similar to that reported for primarily successful PTA, thereby supporting the widely accepted policy of selective stenting as a rescue procedure after unsuccessful balloon angioplasty. Finally, LIF is able to mimic the serum effect to act synergistically with WNT proteins to inhibit ES cell differentiation. In spite of the encouraging results it is considered that there are no grounds for altering the present basis of vasectomy counselling in which the operation is described as likely to be irreversible. Hexafluorodiethyl ether (a volatile convulsant) decreased the GABA-response of the both alpha3beta2gamma2s and alpha3beta2 constructs without generating a surge current. Localization and accumulation of fibronectin in rabbit fetal lung tissue. The aim of this study was to define the optimal treatment for patients with symptomatic intraluminal carotid artery thrombus (ICAT). Properties of some of these mAbs are reported, including affinity, fine specificity and ability to bind to IgE on B lymphoma cells or mast cells. Although class II PI3Ks have the potential to make the same phosphoinositides as class I PI3Ks, their precise cellular role is currently unclear.

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This study explores models of how people perceive moral aspects of socio-scientific issues. Second, actual changes in the number of patients in participating GP-practices were analyzed. In this case report, we describe an aggressive gross squamous cell carcinoma mass arising from a large pedunculated-type FEP located at the lower limb, which, to our knowledge, has not been reported yet. The concept of a dynamic seat, which allows movement of a seat with respect to the wheelchair frame, has been suggested as a potential solution to provide greater freedom and safety. For the detection task of a static, low-contrast, low-spatial-frequency iodine contrast material detail embedded in a 20 cm thick soft-tissue phantom, the greatest contributions for further improvement could be achieved by improved antiscatter devices, x-ray spectrum modification, and by decreasing the absorption in the material layers in front of the CsI phosphor of the XRII.

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The study was not sufficiently powered to detect a difference in disability or death at 2 weeks. Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets. Quantitative information in the genome can thus be transformed into constants determined from the nucleotide sequences. Compared with gelfoam, both sepragel and nasopore caused less histologic alterations. Seasonal changes of serum sex steroids concentration and aromatase activity of gonad and brain in red-spotted grouper (Epinephelus akaara). Compensatory evolution of interacting gene products through multifunctional intermediates. Impairment by allyl isothiocyanate of gastric epithelial wound repair through inhibition of ion transporters.

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In the ethylene-insensitive etr1-1 and ein2-32 mutant lines, both Arabidopsis basic-chitinase induction and seedling-growth responses were completely disrupted, whereas the weaker etr1-2 allele eliminated the chitinase-induction response but only partially disrupted the seedling responses. A simple microindentation technique for mapping the microscale compliance of soft hydrated materials and tissues. Sequential neurological and intellectual recovery after childhood near-drowning is discussed. These patients also spent a shorter time in hospital in spite of longer second stages of labor. The anemia of chronic disease (ACD) results from 3 major processes: slightly shortened red cell survival, impaired reticuloendothelial system iron mobilization, and impaired erythropoiesis. Patients were randomized to receive blinded solutions of either lorazepam or midazolam by continuous infusion. Ready-to-drink (RTD) tea is a popular beverage in many countries. Infections established by the direct transfer of adult worms were essentially normal both in terms of their survival and reproduction and in their stimulation of, and susceptibility to, host immune responses. mauritiana is probably the result of introgression of an infected D.

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Light pulses did not induce c-jun immunoreactivity at any circadian phase tested. Many treatments for persons with severe mental illness are provided by mental health teams. Pre-incubation of platelets with gangliosides increased adhesion at low shear to a level comparable to high shear alone. The effect of room size and general ventilation on the relationship between near and far-field concentrations. Enteroclysis, the infusion of contrast medium directly into the small bowel, is a precise, rapid method for thorough small bowel examination. The affinity-selected peptides derived from the biopanning were analyzed by the receptor ligand contacts (RELIC) suite of programs, which is a bioinformatics tool for combinatorial peptide analysis and identification of protein-ligand interaction sites. The clinical and cytogenetic characteristics of 42 patients diagnosed with secondary myeloid neoplasms in one institution were retrospectively evaluated. Under the auspices of the Canadian Rehabilitation Council for the Disabled, a follow-up study on young adults with cerebral palsy between the ages of 17 and 25 years was carried out by means of a questionnaire. It was observed that IgG could be repeatedly adsorbed and desorbed without significant loss in adsorption amount.

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Radioisotope clearance methods in the diagnosis of kidney diseases. Patients with apnea-hypopnea index greater than 40/hour during an overnight sleep study and who were reluctant to receive nasal continuous positive airway pressure (nCPAP) therapy were included. This work aimed at assessing effects of surgical treatment and post-operative rehabilitation of chronic hyper trophic laryngitis by videolaryngostroboscopy and the GRBAS scale. mAgrin, on the other hand, enabled LmDeltaLG to form an extracellular matrix on cell surfaces without increasing accumulation of non-polymerizing laminins. Its psychoactive ingredient, delta9-tetrahydrocannabinol (THC), produces a variety of effects in animals and humans that are probably mediated by specific cannabinoid receptors in the brain and interactions with several neurotransmitter and neuromodulator systems. Neither tumour had recurred, 19 and 2 years after treatment, thus confirming the good prognosis commonly associated with this tumour. This suggests a need both for more model sensitivity to small environmental fluctuations for the incorporation of a photorespiration function into the model.

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Small molecule vanilloid TRPV1 receptor antagonists approaching drug status: can they live up to the expectations?. The hypothesis that nifedipine may cause an insidious but reversible change in glucose tolerance, similar to that associated with thiazide therapy, was studied in six nondiabetic and six noninsulin-dependent diabetic patients with hypertension. Prevalence and clinical features of abdominal migraine compared with those of migraine headache. Ten pigeons that were not vaccinated or challenged served as negative controls. This study investigates whether and to what extent three widely used cCBT programs for depression incorporate and convey key features that serve to establish, develop, and maintain a therapeutic alliance with program users. This unprecedented phenomenon may be due to antiretroviral therapy. Our findings underscore the complexity of heart-lung interaction in determining pulmonary hemodynamics in left heart failure. Imaging of vasculature by using FCFM revealed a single blood vessel or vasculature network. Effects of anticholinergic drugs on xanax bar pill id epileptic activity from amygdala and frontal cortex.

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The proliferation and survival of cultured rat VSMCs were reduced by rosiglitazone, which was mediated by inhibition of ERK and activation GSK-3beta, without change of Akt. Abnormalities of endothelial function may contribute to atherosclerosis before development of overt diabetes. Str., Hylocomium splendens (Hedw.) B.S.G.), Scots pine (Pinus sylvestris L.), common birch (Betula pendula Roth.), aspen (Populus tremula L.) and English oak (Quercus robur L.). To study this in greater detail, the community structure of methano- and methylo-trophic bacteria was investigated in a rice field in northern Italy during the summer 1999 and compared to a microcosm study described previously. We described the results with regard to study design, calendar period, geographic locale, and level of the socioeconomic measures (individual or ecological). The anterior putamen sends excitatory peptidergic (substance P) pathways to the globus pallidus internus (striatopallidal pathway) and to the substantia nigra reticulata (striatonigral pathway). This survey of parents who experienced the death of a child during their lifetime explores and extends current understanding of the complex emotional response of grief.

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