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Adglim

Adglim lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally.

Other names for this medication:
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Also known as: Glimepiride

Description

Adglim (glimepiride) is an oral diabetes medicine that helps control blood sugar levels.

Adglim is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.

Insulin or other diabetes medicines are sometimes used in combination with Adglim if needed.

Dosage

Usual Adult Dose for Diabetes Type 2:

Initial dose: 1 to 2 mg orally once a day Maintenance dose: Increase in 1 or 2 mg increments no more frequently than every 1 to 2 weeks based on glycemic response Maximum dose: 8 mg per day Comments: -Administer with breakfast or first main meal of the day. -In patients who are at increased risk for hypoglycemia, start with 1 mg orally once a day and titrate slowly. -When patients are being transferred to this drug from a longer half-life sulfonylurea, monitor 1 to 2 weeks for overlapping drug effect. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1 mg orally once a day; titrate slowly and monitor closely

Usual Pediatric Dose for Diabetes Type 2:

Not recommended because of adverse effects on body weight and hypoglycemia.

Detailed Adglim dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An Adglim overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions).

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Adglim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Adglim if you are allergic to glimepiride, sulphonamides, or if you have:

an allergy to sulfa drugs; or diabetic ketoacidosis (call your doctor for treatment).

To make sure Adglim is safe for you, tell your doctor if you have ever had:

heart disease; liver or kidney disease; or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Adglim may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using Adglim if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Adglim for a short time just before your due date.

Medications similar to glimepiride have caused severe hypoglycemia in newborn babies whose mothers used the medicine near the time of delivery. If you take glimepiride during pregnancy, stop taking this medicine at least 2 weeks before your due date.

If you breastfeed while taking glimepiride, call your doctor if your baby shows signs of hypoglycemia (extreme drowsiness, feeding problems, mottled skin, blue lips, feeling cold or jittery, or having a seizure).

Adglim is not approved for use by anyone younger than 18 years old.

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Assessment of spline-based 2D-3D registration for image-guided spine surgery. Its bark macerate is popularly used in Brazilian folk medicine for the treatment of peptic ulcer, wound healing and inflammation. Manufacturing methods, deformation behavior and temperature dependence of the device will be briefly reviewed. Collagen fragmentation in ruptured canine cranial cruciate ligament explants. Chronic obstructive pulmonary disease (COPD) is the internationally preferred term for chronic, progressive lung disorders which are characterised by airflow limitation that is not fully reversible. strain O-7 and its physiological role in the chitinolytic system. Here, we report on seven new cases of fetal onset NPC of whom two were diagnosed in utero and five postnatally.

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Lipolysis, lipid oxidation, ketone body synthesis, tailored endogenous glucose production and uptake, and decreased glucose oxidation serve to protect against excessive erosion of protein mass, which is the predominant supplier of carbon chains for synthesis of newly formed glucose. Bacterial meningitis in the neonate differs from meningitis in the older infant and child in a number of ways. We describe a safe and simple method of repairing an acute rupture of the distal biceps tendon using a single limited (3 cm) anterior approach, a suture anchor, and the use of a plastic sheath (arthroscopy cannula or barrel of a 2 ml syringe) to protect the adjacent neural structures and to remove the need for extensive dissection and retraction in order to protect these structures. Quercetin-induced apoptosis in colorectal tumor cells: possible role of EGF receptor signaling. The morphological findings in the lymph nodes and the postmortem serological findings are described in detail. High-dose methotrexate in combination with interferons in the treatment of malignant pleural mesothelioma. Reactivity of the mesenteric bed arteries of normotensive rats exposed to chronic social stress.

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The mean number of orgasms reported per day was lower in patients than in normal subjects during both treatment conditions, although one patient reported orgasms during drug treatment only. esculenta is composed of numerous islet-like structures, which contain several small somatostatin-immunoreactive cells arranged in the form of clusters. Production, purification, and composition of staphylococcal alpha toxin. The phosphoprotein patterns were dramatically altered in cells defective for TCR/CD3 expression, and were recoverable by reconstitution of correctly assembled TCR, suggesting that CD4 uses TCR/CD3-associated tyrosine kinases to signal. Effect of multiple doses of montelukast, a CysLT1 receptor antagonist, on digoxin pharmacokinetics in healthy volunteers. To evaluate the available evidence in peer-reviewed publications about the outcomes and safety of interventions for toxoplasma retinochoroiditis (TRC). But specific IgE may just has the same effect in the pathogenesis. The conditional mutant NP1 of Tetrahymena thermophila forms a normal oral skeleton at the permissive temperature (28 degrees C), but forms an abnormal one at the restrictive temperature (37 degrees C).

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Fear conditioning following unilateral temporal lobectomy: dissociation of conditioned startle potentiation and autonomic learning. The effect of long-term La treatment on patients with chronic renal insufficiency needs to be evaluated. Fourteen days after grafting, the time to peak tension and the half-relaxation times of nerve-intact grafts were shorter than those of standard grafts, but both were longer than control values. In this study, the SUVmax of the prostate lesions and the pelvic muscles were measured and their ratios (SUVmax-P/M ratio) were calculated. Divided sphincter musculature resulted from obstetrical injury in 23 and previous anorectal surgery in 17. In the two cases of placenta percreta, the placenta demonstrated transmural extension through the uterus (percreta) on MRI. Studies using projective techniques, attribution theory, measures of needs values traits, and self-report inventories are summarized as they relate to heroin addicts. Nonsurgical treatment of the primary tumor in four consecutive cases of metastasized colorectal carcinoma.

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Measles and rubella vaccination of two million Iranians: complications in vaccinees aged 5-25 years. Immunohistochemical localization of a prostatic secretory protein of 94 amino acids in normal prostatic tissue, in primary prostatic tumors and in their metastases. Echocardiography, imaging of coronary and carotid arteries, and assessments of both endothelial function and arterial stiffness have recently been employed to address this question. The pharmacological regulation of cell death is discussed in order to investigate the subsequent effects related to cell regeneration following radiation injury. Proportion of geometrical hydroperoxide isomers generated by radical oxidation of methyl linoleate in homogeneous solution and in aqueous emulsion. While the prognosis of patients with severe lupus manifestations continues to improve, prevention of relapse remains a clinical challenge. The 5q31 locus is frequently deleted in myelogenous leukemia and other cancers. The aliquot giving rise to antigen expressing cells was then subdivided until a single antigen encoding colony was obtained. It is thought that different cofactors target Hsp90 to different sets of substrates. Biomarkers could also be used to test the effectiveness of environmental controls.

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Until recently, refusal to submit to recommended care was considered suicide. Normative data and psychometric properties of the child behavior checklist and teacher rating form in an Iranian community sample. We did not find impairment of glare vision following this procedure. Perhaps it is not surprising that in the critical care environment, where lives are frequently on the line, off-label use of certain drugs is relatively common. In this work, we obtained a biophysical characterization of the native and phosphorylated RD in solution by employing complementary structural methods. Designing graduate training programs in conservation medicine-producing the right professionals with the right tools. Laminin and fibronectin promote the chemotaxis of human malignant plasma cell lines. Comparison of mechanical reliability of original and enhanced Mentor Alpha I penile prosthesis. SEMS placement is a safe and effective treatment modality for palliation of dysphagia due to malignant esophageal strictures.

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Cost effectiveness of preventive home visits to the elderly: economic evaluation alongside randomized controlled study. The influence of chelating agents on the prooxidative effect of a hydrogen peroxide producing methylhydrazine compound. Blocking NF-kappaB activity by dexamethasone-induced overexpression of Ci-IkappaB abrogated the repression of apoptosis in test cells. Prevalence of GJB2 (CX26) gene mutations in south Iranian patients with autosomal recessive nonsyndromic sensorineural hearing loss. Other areas of great current interest are the mechanisms by which certain long chain polyunsaturated fatty acids are made available for conversion to oxygenated, biologically-active derivatives, the metabolic interactions between different polyunsaturated fatty acids, particularly n-3 and n-6 fatty acids, the cellular roles of the C22 polyunsaturated fatty acids, and the functions of particular molecular species of phospholipids in membrane-mediated events. Delivery of therapeutic or diagnostic agents across an intact blood-brain barrier (BBB) remains a major challenge. A role for serines 426 and 427 in regulating the rate of internalization.

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Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor, which has been associated with total and cardiovascular mortality in various clinical settings. Computed tomography appearances of bronchogenic carcinoma associated with bullous lung disease. Endogenous hydrogen sulfide has a powerful role in inhibitory neurotransmission to the pig bladder neck. However, relatively little is known about participant characteristics that reliably predict either success or failure in these treatment settings. Recently, a MIT governed by disorder was observed in crystalline phase-change materials. Treatment was associated with a decline in the total symptom score according to the Brief Psychiatric Rating Scale and the score for positive symptoms showed a relatively high correlation with reduction in PDE level in the left temporal lobe. Several problems in hormonology and regulation of the thyroid gland. Quantitative analyses of morphologic findings are the condition of clinico-pathological correlation studies. Escherichia coli: a brief review of diarrheagenic pathotypes and their role in diarrheal diseases in Iran.

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Cultural characteristics of L forms of amoxil dose dental prophylaxis Staphylococcus aureus and Streptococcus liquefaciens. Molecular characterization of infectious clones of the minute virus of canines reveals unique features of bocaviruses. Left coronary ostial obstruction after aortic valve replacement with a supra-annular aortic valve. ODP/Al and OP/Al were studied by friction force microscopy, a derivative of AFM, to better understand their micro-/nano-tribological properties. At-risk patients require a careful history and physical examination aimed at ruling out secondary causes, including systemic disease and certain drugs. A role of an analyst in clinical laboratory and an expert in toxicological forensic areas has been discussed. Looking ahead: questions for and about behavioral scientists and practitioners. Therefore, antisense peptide-PNAs can efficiently and specifically inhibit both reporter and endogenous essential genes in mycobacteria. After purification by hydrophobic interaction chromatography and gel filtration, the lipase/esterase terase activity of active fraction was 61.7 times higher than the crude enzyme and the purity of 23 kDa protein increased more than 400 times. Different isoforms of haptoglobin have been found in the serum of patients with EOC.

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Fauna of parasitic nematodes from Chiroptera of the Samarskaya Luka has been studied. These two disorders are the most common examples of hyperactive cranial rhizopathy and are frequently caused by vascular compression of these cranial nerves at the nerve root entry and exit zone in the brain stem, which leads to paroxysmal ephaptic transmission. The presence of sonographic abnormalities is common in ballet dancers, but only the presence of focal hypoechoic changes predicts the development of future tendon-related disability. Through an established protocol, it was possible to isolate thrombin, as well as the platelet-rich plasma (PRP) and platelet-poor plasma (PPP) fractions. Current practices may have swung toward excessive testing, especially in patients whose surgical risks are low or moderate.

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The transport activity of albendazole tablet uses in bengali SGLT2 was determined by FCM choosing 2-NBDG as the detection target. This assay has the potential of being used in high-throughput screening of chemical libraries for the identification of novel compounds that specifically modulate the expression of MCM. Cardiac complications in patients subjected to emergency surgery for gastrointestinal diseases. However, the generalizability of the effects of the programme is still to be determined. A convenience sample of 102 women with HIV/AIDS completed the Lee Fatigue Scale in the morning and evening. These results illustrate how tissue-specific transcription factors cooperate with general signalling pathways to regulate gene expression in a tissue-specific manner.

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