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Adefin (Nifedipine)

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Adefin is a dihydropyridine calcium channel blocker. Adefin is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Adefin was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Adefin works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Adefin, Adipine, Bresben, Calcianta, Citilat, Conducil, Conetrin, Cordafen, Cordilat, Corinfar, Emaberin, Fenamon, Ficard, Glopir, Herlat, Hexadilat, Hypan, Macorel, Myogard, Nefelid, Nidipine, Nifecap, Nifedalat, Nifedical, Nifedipine, Nifedipinum, Nifelong, Nifeslow, Nifestad, Nipidin, Nipress, Nirena, Nycopin, Siopelmin, Tredalat, Viscard

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin XL. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adefin are:

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Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

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Research frequency of puerperal disorders in nulliparous women who had cesarean section in University Hospital Mostar in year 2004 and given results compared with nulliparus women who had vaginal mode of delivery. Expression of Neuropeptide Y gene in mouse testes during testicular development. sanguineus the crystallinity was found to increase during some stages of degradation. No observable damage in either the cell wall or the cell membrane had taken place during 4 hr, but by 20 hr extensive damage of these two structures was apparent. Plant growth inhibitors isolated from sugarcane (Saccharum officinarum) straw. The isolation and characterization from rabbit reticulocytes of two forms of eukaryotic initiation factor 2 having different beta-polypeptides. Standardised conditions before and after application of furosemide are necessary. HBOT was well tolerated and 9 of the 10 patients completed a full HBOT treatment program. Predictors of a sustained response to exercise training in patients with chronic heart failure: a telemonitoring study.

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Sex hormones in the regulation of bone and cartilage metabolism: an old paradigm and a new challenge. Moreover, in a specific proliferation test measuring IL-1 activity, when macrophage supernatants from female F1 produced a 13-fold increase of thymidine incorporation, supernatants from male F1 only produced a three-fold increase. In this study we analyzed the effects of successive doses of 500 or 1,000 IU of Dysport, endoscopically injected into the detrusor muscle. It is well recognized that a wide variety of chemicals exert toxic effects on the structure and function of the nervous system. Deficient antibody-dependent cellular cytotoxicity against human immunodeficiency virus (HIV)-expressing target cells in perinatal HIV infection. 4-Methylumbelliferil-2-acetamido-2-deoxy-beta-D-glucopyranoside and 4-methylumbelliferil-2-acetamido-2-deoxy-beta-D-glucopyranoside-6-sulfate were used as fluorigenic substrates. Mitochondrial 18-hydroxylation of endogenous and exogenous corticosterone, however, as well as 18- and 11 beta-hydroxylation of deoxycorticosterone, were increased in obese hypertensive rats, both when compared with non-obese hypertensive siblings and when compared with healthy Sprague-Dawley rats. A method is described for the growth of bacteria within dialysis tubing to yield extracellular enzymes, or, possibly, other nondialyzable extracellular products, in concentrated form. The one-year prospective, observational study was carried out in 1989 in 80 general practices in Limburg, the Netherlands.

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Two statements are of special importance for pathophysiology: 1. The finding that only a small number of brain stem cholecystokinin-like immunoreactive neurons project to the spinal trigeminal nucleus supports the hypothesis that most of the cholecystokinin input to the spinal trigeminal nucleus arises from primary afferent trigeminal fibers. In addition, we elucidated the ORF sequences of all segments from another bovine RVC, the Toyama strain, detected in Toyama Prefecture, Japan, in 2010, in order to investigate genetic divergence among bovine RVCs. The poor development of systems of occupational surveillance in Spain is an important obstacle for implementing effective occupational health programmes. haplocalyx extract, including 9 new minor constituents reported for the first time. Nutritional profile and inflammatory status of hemodialysis patients. This is the first study demonstrating differential effects of various antidepressants on the time course of serial DEX/CRH test results in depressed patients. Background: Differential identification of baboon alpha, beta, and gamma herpesviruses is an essential technology in order to monitor xenozoonotic transmission of baboon viruses to foreign species organ and/or cell recipients. Shoulder external rotation tendon transfers for brachial plexus birth palsy. bovis diseases have been documented as frequent and economically important in the United States, there are no published reports on the antimicrobial activity of approved compounds against US strains.

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Sampling the soil in long-term forest plots: the implications of spatial variation. Control of drug-resistant pathogens in endemic settings: contact precautions, controversies, and a proposal for a less restrictive alternative. The production of Gag-Env pseudovirions by canarypox HIV vaccine vectors may have important implications for future HIV vaccine design. Peripheral blood eosinophils were isolated with the new isolation kit as well as conventionally with anti-CD16-conjugated MicroBeads. The genetic susceptibility of Mastomys to develop such tumors is a feature reminiscent of the situation in patients with the MEN-1 Zollinger Ellison syndrome, in whom tumor-induced hypergastrinemia, promotes the development of gastric carcinoids. Effect of trace metals on synthesis of exoproteins and exotoxins by Staphylococcus aureus. These findings link its pathological plasticity in critical limb ischemia to impaired neovascularization, prompting further studies to probe the microvascular therapeutic potential of S100A1. When rat aorta rings were incubated with the SPK inhibitor DL-threo-dihydrosphingosine (DTD), there was a concentration-dependent reduction of Ach-induced vasorelaxation, implying a consistent contribution of sphingolipid pathway through intracellular sphingosine release and phosphorylation. One assisted venous drainage technique, vacuum-assisted venous drainage (VAVD), the aid of a vacuum in the venous reservoir, is now widely used to augment venous drainage during cardiopulmonary bypass (CPB) procedures. To define the role of neodymium:yttrium-aluminum-garnet (Nd:YAG) lasers in root canal disinfection along with a minimally invasive treatment concept.

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Monitoring of orthotopic liver transplantation in children by means of serial graft biopsies. The use of carrageenan in mixture with microcrystalline cellulose and its functionality for making tablets. This technology offers an effective method for delivery of oligopeptides and oligonucleotides into Dictyostelium. Rapid detection of methicillin-resistant staphylococci by multiplex PCR. The results provide information critical for designing effective prevention measures against HIV transmission. Phorbol ester effects at hippocampal synapses act independently of the gamma isoform of PKC.

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We have previously shown in a nude mouse xenograft model that restoration of CEACAM1(a)-4L expression in human prostate carcinoma cells (PC-3) suppresses tumorigenicity, an effect observed with carcinomas from several other tissues but never established for hepatocellular carcinomas. Protective effect of Acorus calamus LINN on free radical scavengers and lipid peroxidation in discrete regions of brain against noise stress exposed rat. When directly injected into the dorsal raphe nucleus 8-OH-DPAT (0.1 microgram/microliter) and ipsapirone (0.2 microgram/microliter), both compounds produce anxiolytic effects. Externally added FGF-9 was more effective in low density cultures, and polyclonal blocking antibody against FGF-9 significantly lowered the ChAT activity. We have observed the occurrence of some neoplasms in IBD patients who developed sustained leukopenia as a result of treatment with 6-MP. Left ventricular mass decreased in all the patients and peak lengthening rate of left ventricular diameter, index of diastolic function, increased in all, with normalization in 5 of the 6 with basal diastolic impairment. It has been proposed that dopamine (DA) sustains up states in striatal medium spiny neurons (MSN). However, such assessments have limitations such as recall bias, averaging, insensitivity to change and variable interrater reliability. Accurate, consistent diagnosis is crucial to risk-stratify patients and facilitate clinical decision making as to treatment versus active surveillance. The weak estrogenic effects of isoflavones and the similarity in chemical structure between soybean isoflavones and the synthetic isoflavone ipriflavone, which was shown to increase bone mineral density in postmenopausal women, suggest that soy or isoflavones may reduce the risk of osteoporosis.

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Involution of the seminiferous epithelium was evident in all testes exhibiting extensive interstitial cell proliferation. Implementation of ion/ion reactions in a quadrupole/time-of-flight tandem mass spectrometer. A total of 861 men completed a battery of questionnaires assessing anxiety, depression, fatigue, insomnia, and quality of life. As an alternative we propose to sum over the observed marker locations along the chromosomal region of interest. For example, several microbial strains recently developed for enzyme production have been engineered to increase enzyme yield by deleting native genes encoding extracellular proteases. The percentage of thyroid cancer cases attributable to specific risk factors can be calculated to focus preventive strategies. Construction and characterization of a pseudo-immune human antibody library using yeast surface display. A20 has been shown to interact with D4, the virally encoded uracil DNA glycosylase (UDG), by yeast-two hybrid and in vitro analysis. In microarray hybridization, EFEMP1 was shown to be significantly up-regulated in L3.6pl cells compared with FG cells.

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Computing techniques for intrapartum physiological data reduction. We previously showed that platelet reactivity at rest is increased in patients with cardiac syndrome X (CSX), but that exercise reduces platelet reactivity in these patients. The literature is reviewed in these contexts, questioning the existence of classical epinephrine neurons. In spite of the monumental challenges, supporters of stem cell research remain convinced of its benefits to future generations. A recording unit and electronic shunt selector for a mass spectrometer.

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An abdominal CT scan revealed, besides this tumour, also metastases in the spleen. The LF(1) epitopes might represent conserved polypeptide epitopes on 2 homologous lobes of lactoferrin. The alternative consideration is that these are simply uncommon species that are very host specific. The activity of GM1 in enhancing the liposome uptake by rat liver appears to be mediated by complement components. We report data from 712,000 respondents aged 20 to 79 to the National Geographic Smell Survey that suggest that exposure to the factory workplace adversely affects the sense of smell, and that these effects interact with age. At the Mayo Clinic since 1982, 360 patients have undergone vocal fold injections with Polytef paste.

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How parasite plastid biosynthetic pathways are fuelled in the absence of photosynthetic capture of energy and carbon was not clear. All the cytology (wet-fixed and air-dried smears) was reviewed by G.M., and the histology sections were reviewed by G.T. Upon transplantation as individual cells according to the standard procedure, ES cells distributed widely to various organ systems of 3 germ layers. This work reviews the fundamental aspects of the MC-SPL process. These mice exhibit severe ataxia, motor paresis, and death before the third postnatal week. Recent insights into the structure, function and biology of cPLA2. Pregnancy termination in the control of the tibial hemimelia dose of ethambutol in tuberculosis syndrome in Galloway cattle. In this study, we analyze the effects of Mre11 loss on the mechanism of vertebrate NHEJ by using a chromatinized plasmid double-strand break (DSB) repair assay in cell-free extracts from Xenopus laevis.

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Although the growth of the soft palate was continuous throughout life, hard palate growth ceased by age 15. Assessment of reference values for DNA damage detected by the comet assay in human blood cell DNA. We aimed to assess the clinical response of patients with pemphigus to a single cycle of rituximab at the dosage used in rheumatoid arthritis. In addition, the use of linkage as a risk mitigation strategy has not been studied properly yet with genetic introgression models. klonopin medication mg A unique feature of the red kidney bean acid phosphatase, which we have found, is that one of the two cysteines of each subunit is involved in the formation of an inter-subunit disulphide. The effect of total blood exchange with PHP solution on cardiac xenotransplantation. The use of evidence-based medical therapy is lower in patients with NOCAD compared with those with OCAD.

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The problems of corticoderm in large injury of soft tissues of crus (a case report). LORETA images of P300 in response to the odd-ball auditory discrimination task revealed a left dominant lateralized high current source density in the temporal lobes in all control subjects. The importance and interest of the analysis of the enantiomers of the active compound and its metabolites in different biological fluids (plasma, urine, cerebrospinal fluid, etc.) are also discussed. DNA from plucked single hairs from ten individuals was extracted by two different methods and subsequently amplified and typed using the AmpliType HLA DQ alpha Forensic DNA Amplification and Typing Kit. In this study, we have measured plasma insulin at fasting and following an oral glucose load and blood pressure after glucose load in 367 (247 non-obese, 120 obese) normotensive and untreated mildly hypertensive subjects. I report a case of delayed, but fatal, perforation of the bladder associated with a medially placed acetabular screw during revision arthroplasty in a rheumatoid patient. Fluorescent polystyrene particles with a nominal size of 50, 200, and 750 nm were administered orally for 3 or 5 days and particle adhesion in the gastrointestinal tract analyzed.

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Nine of the 64 patients had radiographic changes suggestive of axial gout. Aceruloplasminemia: a rare disease - diagnosis and treatment of two cases. Update: outbreak of legionnaires disease in Norway traced to air scrubber. This method allowed us to detect and quantitate carbonyl groups in the albumin, alpha-2, beta and gamma-globulin fractions. Rac1 is required downstream of integrins for activation of the PrlR/Stat5 signaling cascade. tularensis in diagnostically significant titre were detected in all 12 serum samples by both tests. Genome-wide DNA methylation assessment showed that epigenetic silencing of selective tumor suppressor genes completed PU.1-initiated transformation of lymphoid progenitors with URE deletion. The fluorescence characteristics of the partial agonist probes were quite similar to those of the analogous full agonist probes and quite distinct from the analogous antagonist probes.

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Electronic excitation to singlet states of 1,3-C4F6, c-C4F6 and 2-C4F6 by electron impact--electron energy-loss spectroscopy and ab initio calculations. By using the SAM to engineer the effective Au work function, we markedly affect the charge injection process. With changes in reimbursement and a decrease in the number of residents, there is a need to explore new ways of achieving high-quality patient care in radiation oncology. Dobutamine stress MR (DSMR) is increasingly used in the clinical routine. These peptides show antimicrobial activities against bacteria and fungi. Band structure calculations indicate that TNAD is an insulator with the band gap of ca. Many of the clinical features of patients with mitral valve prolapse can logically be attributed to abnormal autonomic neural function. As far as we know only two cases of severe vasculitis following anti-TNF treatment have been reported. The contents of soluble saccharides and amino acids in different organs were low in plants of 1-2 years old. One STD (L(r)/1000) is slightly more toxic than one unit of the international standard (L(f)/1,000).

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Regulation and function of estrogen and progesterone receptor systems. The increased susceptibility to infectious agents is mainly related in the inability of the leukocytes to adhere to certain surfaces, because all adherence-related functions of the neutrophils that lead to bacterial killing are impaired. Diagnostic usefulness of a T-cell-based assay in patients with miliary tuberculosis compared with those with lymph node tuberculosis. To this end, we have first computed estimates of the signal-to-noise ratio gain between the original and noise-reduced signals. In hip resurfacing, the femoral head is retained, which makes it much more difficult to access the acetabular cup.

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Detection of anti-Chlamydia trachomatis antibody by means of enzyme immunoassay using synthetic peptide antigen. The aim of the present study was to evaluate possible effects of general anesthesia on CSF pressure values. The number of fenestrations in alveolar septa of the lung was determined by using serial sections to directly count the number of fenestrae in a known volume of lung. The extracellular-side constriction region of this AQP0 structure was significantly larger than that of the EM-based model and similar to that of the highly water permeable AQP1. Mechanical factors in the maintenance of normal corneal deturgescence. Inhibition of bombesin-stimulated gastric acid secretion by secretin, glucagon and caerulein does robaxin show up on a drug screen in patients with duodenal ulcer. An important component of practical JSCC schemes is a distortion model that can predict the quality of compressed digital multimedia such as images and videos. Assessment of left atrial appendage function with transthoracic tissue Doppler echocardiography.

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The protrusion of the arterial wall was clipped and coated with Bemsheet soaked in Biobond. We measured serum VEGF and bFGF levels from patients with soft-tissue sarcomas and correlated serum VEGF and bFGF levels with tumor status at surgery and histological grading. The records of 189 consecutive patients with cataract and posterior segment pathology necessitating phacovitrectomy were retrospectively analyzed. Interpretations in terms of sensitivity and pseudosensitivity to the experimental contingencies are explored. Pre and post-treatment histopathological changes in atrophic rhinitis. These proteases were in all cases labelled by surface radioiodination. Appropriate quantitative three-dimensional parameters describing the investigated structure were introduced, such as the model-independent thickness and the structure model index. Analyses were performed before, during, and after each surgical procedure. Higher plasma levels of HDL-C are associated with a lower risk of incident CKD in a large cohort of type 2 diabetic adults independently of numerous confounding factors.

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We have initiated studies designed to evaluate the response of zebrafish to antipsychotic drugs. Turkey coronavirus is more closely related to avian infectious bronchitis virus than to mammalian coronaviruses: a review. Through the use of a reference titration curve ELISA could be used as a semi-quantitative system to determine antibody levels in test sera. Neural conversion of ES cells by an inductive activity on human amniotic membrane matrix. We propose a continuum model for the dynamics of particles in polymer matrices which encompasses arbitrary size ratios of the polymer and particle. Sodium hydride is a common reagent for substrate activation in nucleophilic substitution reactions. Further studies are necessary to confirm the migraine prophylactic value of metoclopramide. Wild birds contribute to maintenance and dissemination of vectors and microbes, including those that impact human, domestic animal, and wildlife health. Cardiovascular state and efficiency of information processing depend from work load in operators of heat power stations. In the Morris water maze, housing had effects on spatial acquisition, while CCX reduced activity, without interfering with spatial memory.

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Genes for Epstein-Barr virus, human cytomegalovirus immediate early xanax xr pill identification antigen and luciferase are abundantly transcribed in Namalwa, rat 9G and X1 cells, respectively. An analysis of the sustainability gap suggests that a crucial missing component in our quest for sustainability is a failure to engage the humanities, along with the biophysical and social sciences, economics, and technology, in the search for solutions. Cholera toxin and pertussis toxin were inhibitory to the incorporation of thymidine into A431 cells in serum-free culture. The lateral sector, which corresponds to the narrow lateral part, transmits the trochlear, frontal, and lacrimal nerves and the superior ophthalmic vein, all of which course outside the annular tendon. Generally, it consists of three phases: i) fast spherulation (phase 1), ii) restoration of shape close to discoid one (phase 2), followed by a second slower spherulation in stomatocyte direction (phase 3). Importance and limitations of chemotherapy among the available treatments for gastrointestinal tumours. Therefore, pharmacological strategies directed to restore the normal responsiveness of the immune system could be efficacious in the treatment of these pathological conditions.

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