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Acroli (Tacrolimus)

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Acroli is used to stop your body from attacking or rejecting your transplanted organ. The typical starting dose will be based on your weight, the type of transplant you received, and the other immunosuppressants you're taking. After a few days, your dose will be adjusted based on your blood tests.

Other names for this medication:
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Also known as: Tacrolimus


Acroli (tacrolimus) weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it.

Acroli is a prescription medicine and is used together with other medicines to prevent your body from rejecting a heart, liver, lung, or kidney transplant.

Acroli is supplied as oral capsules, granules for oral suspension, and as an injection for intravenous use.

Acroli capsules and oral granules are immediate-release medicines and they are not the same as tacrolimus extended-release tablets or tacrolimus extended-release capsules. Your healthcare provider should decide what medicine is right for you.


A nurse or other trained health professional will give you this medicine in a hospital. It is given through a needle placed into one of your veins. Your doctor may let you stay for at least the first 30 minutes after the start of the infusion and at frequent intervals thereafter.

You will only receive this medicine for a few days. Then your doctor will switch you to the oral (by mouth) form of tacrolimus.

This medicine comes with a patient information insert and patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You should not eat grapefruit or drink grapefruit juice while you are receiving this medicine. Grapefruit and grapefruit juice will increase the amount of medicine in the body.

Detailed Acroli dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

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The most common side effects associated with Acroli are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Generic Acroli if you are allergic to Generic Acroli components. Do not use Generic Acroli while you are pregnant or have nurseling. Do not take Generic Acroli if you use cyclosporine (such as Gengraf, Neoral, Sandimmune). Try to be careful with Generic Acroli usage in case of taking bromocriptine (Parlodel), carbamazepine (Tegretol), cimetidine (Tagamet), cisapride (Propulsid), clarithromycin (Biaxin), clotrimazole (Mycelex, Lotrimin), danazol (Danocrine), diltiazem (Cardizem), erythromycin (E-Mycin), fluconazole (Diflucan), ganciclovir (Cytovene), HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir), itraconazole (Sporanox), ketoconazole (Nizoral), methylprednisolone (Medrol), metoclopramide (Reglan), nefazodone (Serzone), nicardipine (Cardene), nifedipine (Adalat, Procardia), omeprazole (Prilosec), phenobarbital, phenytoin (Dilantin), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane), spironolactone (Aldactone), triamterene-containing drugs (Dyazide, Dyrenium, Maxzide), troleandomycin (Tao), verapamil (Calan, Isoptin), and vitamins, amiloride (Midamor, Moduretic), cyclosporine (Neoral, Sandimmune), oral contraceptives (birth control pills). Try to be careful with Generic Acroli if you suffer from or have a history of kidney or liver disease, diabetes, high blood pressure. Avoid ill people. Avoid grapefruit or grapefruit juice. Protect your skin from the sun. Avoid vaccinations. Be careful with Generic Acroli if you are going to have a surgery. Avoid alcohol. It can be dangerous to stop Generic Acroli taking suddenly.

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